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So, plagues and epidemics have ravaged humanity throughout its existence, often changing the course of history. Scientists and medical researchers have for years have differed over the exact definition of a pandemic (is it a pandemic, or an epidemic), but one thing everyone agrees on is that the word describes the widespread occurrence of disease, in excess of what might normally be expected in a geographical region.
Cholera, bubonic plague, smallpox, and influenza are some of the most brutal killers in human history. And outbreaks of these diseases across international borders, are properly defined as a pandemic, especially smallpox, which throughout history, has killed between 300-500 million people in its 12,000-year existence. Throughout the course of history, disease outbreaks have ravaged humanity, sometimes changing the course of history and, at times, signaling the end of entire civilizations. Here is a timeline of the 20 deadliest epidemics and pandemics, dating from prehistoric to modern times.
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Echoes of Time v2 by Kevin MacLeod is licensed under a Creative Commons Attribution license (
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